Nosodes and sarcodes (homeopathic remedies gained primarily from disease products respectively organs of human or animal origin) are groups of drugs which were added to the homeopathic Materia Medica in the 1830s. Most substances used in nosode or sarcode therapy have a long medical tradition, with some even going back to the pre-Christian period. My contribution first describes therapeutic practices that use these substances and then juxtaposes them with their use in the early days of homeopathic nosode and sarcode therapy. The investigation shows, on the one hand, that there are aspects common to both approaches that go far beyond the mere choice of substances. On the other hand, it demonstrates the effect the inclusion of human or animal body substances in the homeopathic Materia Medica has had on homeopathy, as their use is no longer in line with what is considered rational.